TP53deletion is not an adverse feature in multiple myeloma treated with total therapy 3
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چکیده
منابع مشابه
Total therapy with tandem transplants for newly diagnosed multiple myeloma.
Between August 1990 and August 1995, 231 patients (median age 51, 53% Durie-Salmon stage III, median serum beta-2-microglobulin 3.1 g/L, median C-reactive protein 4 g/L) with symptomatic multiple myeloma were enrolled in a program that used a series of induction regimens and two cycles of high-dose therapy ("Total Therapy"). Remission induction utilized non-cross-resistant regimens (vincristine...
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A 46-year-old woman with a medical history of a multinodular goiter presented to the department of dermatology with extensive yellow papules and nodules surrounding both eyelids that had developed over the past 3 years. A skin biopsy was done that showed chronic granulomatous dermal inflammation and foreign body giant reaction consistent with juvenile xanthogranuloma after ruling out a ruptured...
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Relapsed/refractory multiple myeloma represents a major challenge in multiple myeloma therapy. For patients with relapsed/refractory multiple myeloma, we developed a treatment schema of metronomically scheduled drug therapy. We identified 186 patients who had been treated with metronomic therapy between March 2004 and January 2012 with a median follow up of 24.2 months. Median age was 61 years ...
متن کاملLow p27 Expression Is an Independent Adverse Prognostic Factor in Patients with Multiple Myeloma
Purpose: To determine the clinical relevance of p27 in multiple myeloma (MM), we examined the relationship between p27 expression at diagnosis and clinical as well as laboratory parameters, including response to chemotherapy and overall survival in 74 previously untreated patients with MM. Experimental Design: Expression of p27 was assessed by immunohistochemistry on formalin-fixed, paraffin-em...
متن کاملLow p27Kip1 expression is an independent adverse prognostic factor in patients with multiple myeloma.
PURPOSE To determine the clinical relevance of p27(Kip1) in multiple myeloma (MM), we examined the relationship between p27(Kip1) expression at diagnosis and clinical as well as laboratory parameters, including response to chemotherapy and overall survival in 74 previously untreated patients with MM. EXPERIMENTAL DESIGN Expression of p27(Kip1) was assessed by immunohistochemistry on formalin-...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2009
ISSN: 0007-1048,1365-2141
DOI: 10.1111/j.1365-2141.2009.07864.x